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KMID : 1098420140220030196
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Korean Journal of Medicinal Crop Science
2014 Volume.22 No. 3 p.196 ~ p.202
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Antidepressant-like Effects of Schisandra chinensis Baillon Water Extract on Animal Model Induced by Chronic Mild Stress
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Kang Min-Gu
Kim Young-Hwa
Im A-Rang
Nam Byung-Soo
Chae Seong-Wook
Lee Mi-Young
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Abstract
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Depression is one of the most common neuropsychiatric disorders and has been associated with the neuroen-docrine system and alterations in behavior. Schisandra chinensis Baillon is one of major medicinal plants used as a Korea medicine and food sources, and has been processed in the fields of various food products and medicinal herbs. The chronic mild stress (CMS) protocol is widely used to evoke depressive-like behaviors in laboratory mice or rat. The CMS procedure induced some behavioral changes that are compatible with the common expectations, i.e. ‘anhedonic’ behavior and can affect corticosterone level. The present study, Schisandra chinensis extract administration by daily gavage from the 3 weeks exhibited an antidepressant-like effect on CMS-induced depression in mice. Schisandra chinensis extract administration at dose of 200 ㎎/㎏ significantly increased the sucrose consumption, and decreased the immobility durations in forced swim test and tail suspension test. Furthermore the corticosterone level decreased than control group. In conclusion, Schisandra chinensis extract showed antidepressant-like effects on sucrose preference test, forced swimming test and tail suspension test based on CMS model.
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KEYWORD
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Antidepressant, Schisandra chinensis Baillon, Chronic Mild Stress, Forced Swimming Test, Tail Suspension Test, Sucrose Preference Test
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